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Chemically defined and animal component-free medium for T cell culture. PRIME-XV T Cell CDM supports viable T cell expansion across different culture vessels.

Size Stock SKU Unit Price Qty
1 L Inquire for Availability 91154-1L

    PRIME-XV T Cell CDM is the first commercially-available, chemically defined, animal component-free medium for the expansion and transduction of human T cells. The formulation is optimized to deliver consistently vigorous growth while maintaining T cell functionality and potency.

    Provides Optimal Performance

    Chemically defined, animal component-free T cell culture medium

    • Supports T cell expansion in static and dynamic automation systems while maintaining functionality
    • Eliminates the adverse effects undefined components cause on T cell phenotypes
    • Supports polarization to targeted T cell types, such as Th1, Th2, cytotoxic T cells, to further possible therapy applications
    • Performs transduction of T cells without requiring spinoculation or transduction enhancers

    Designed and manufactured to facilitate transfer from research to clinic. Supported by robust raw material controls and supply chain management:

    • FDA, Federal, and State registered - cGMP-compliant manufacture
    • EN ISO 13485:2016 certified
    • MDSAP certified
    • Extensive QC testing including functionality, sterility (USP <71>), endotoxin (USP <85>), and mycoplasma (USP <63>)
    • Drug Master Files (DMFs) filed with the FDA – available upon request

    Custom sizes and packaging available upon request.

    Contact us for international pricing and custom formulations.

    PRIME-XV T Cell CDM supports viable T cell expansion across different culture vessels

    Figure 1: (A) Fold expansion of CD3+ cells in PRIME-XV T Cell CDM is robust across the 3 documented culture systems, performing as well as or better than FBS-supplemented RPMI and commercially-available XSF media. (B) Viability is maintained at or above 85% by the end of the culture period in all 3 cell culture systems. Though significant inter-donor variability is observed, these data are representative of 3 donors, analyzed on day 14 (G-Rex) or day 9 (Quantum Bioreactors).

    Figure 2: Enhancer-free transduction in PRIME-XV T Cell CDM is equal to or better than commercially-available xeno-free media and FBS-supplemented RPMI. Transduction efficiency of GFP reporter-positive cells at day 14 of expansion are robust in the chemically defined medium, even in the absence of transduction enhancers.


    Publications, presentations, and protocols available for download

    • Protocols support G-Rex and Quantum
    • Protocols for plates and flasks can be provided upon request.


    This product is shipped at 2-8°C with cold packs. Upon receipt, store immediately at 2-8°C and protect from light.
    Shelf Life
    Handle using aseptic techniques to avoid contamination. Unopened liquid medium is stable for 12 months from date of manufacture.
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