Recombinant Human IL-15

In stock

Catalog ID

100-86

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-86-10UG	$176.00
10 µg (Animal-Free)	Inquire for Availability	100-86AF-10UG	$192.00
100 µg	Inquire for Availability	100-86-100UG	$509.00
100 µg (Animal-Free)	Inquire for Availability	100-86AF-100UG	$555.00
500 µg	Inquire for Availability	100-86-500UG	$2,526.00
500 µg (Animal-Free)	Inquire for Availability	100-86AF-500UG	$2,778.00
1 mg	Inquire for Availability	100-86-1MG	$4,211.00
1 mg (Animal-Free)	Inquire for Availability	100-86AF-1MG	$4,632.00

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Details

Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	IL-T
Accession Number	P40933
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 12.9 kDa (115 aa)
AA Sequence	MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium bicarbonate, pH 8.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 97%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	CTLL-2 cell proliferation	≤ 1 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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