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Life Whisperer
Life Whisperer is an objective, non-invasive web application to aid in the decision-making process of embryo selection that uses AI-based algorithms to assess Day 5 embryo morphological features correlating with the likelihood of clinical pregnancy and embryos being euploid.
Objective
Increased consistency, accuracy & confidence
Receive confidence scores of 0 to 10 correlating with the likelihood of clinical pregnancy and embryos being euploid
Easy-to-Use
Drag-and-drop functionality helps you make key decisions
Quickly integrate the AI-based assessment into your embryo selection workflow
Cost Effective
No expensive equipment, maintenance, or subscription fees
No capital outlay is required with minimal to no disruption to the IVF workflow
Patient Friendly
Give patients a first-hand look at the decision-making process
Included Patient Reports increases transparency, patient knowledge and opens discussion during the IVF process
A Versatile Tool for More Informed Decisions
Comprised of two separate components, Life Whisperer Viability and Life Whisperer Genetics help maximize success and help patients build families.
Life Whisperer Viability
Assists in the selection of blastocysts that have a greater likelihood of pregnancy. In a simulated cohort analysis, Life Whisperer Viability improved selection of viable embryos which led to a 12% reduction in the number of cycles needed to achieve clinical pregnancy compared to Gardner grading methods.1
Figure 1. Life Whisperer Viability Time to Pregnancy vs Gardner Grading in a Simulated Cohort Study
| Life Whisperer Viability | Gardner Grading (3BB Threshold) |
|
| Average Time to Pregnancy (in number of cycles): |
1.65 | 1.88 |
| Reduction in Time to Pregnancy: | 12.2% |
Life Whisperer Genetics
Assists in the selection of embryos that have a greater likelihood of being euploid prior to further testing or transfer, offering a non-invasive glimpse of embryo genetic integrity. In a simulated cohort study, Life Whisperer Genetics identified the top-ranked embryo as euploid in 82.4% of cohorts.2
Figure 2. Life Whisperer Genetics Performance in a Simulated Cohort Study
| Life Whisperer Genetics | Random | |
| Selection Probability:* | 82.4% | 65.2% |
| Probability Improvement: | 26.4% |
*Proportion of cohorts with top ranked embryo as euploid
*The theoretical maximum accuracy for prediction of this endpoint based on evaluation of embryo quality is estimated to be ∼80%, with the remaining 20% affected by patient-related clinical factors, such as endometriosis, or laboratory process errors in embryo handling, etc., that could lead to a negative pregnancy outcome despite a morphologically favorable embryo appearance.2
**Accuracy improvement = (Life Whisperer Viability accuracy – embryologist accuracy) / embryologist overall accuracy * 100%)
Objective Assessment of Embryo Viability and Genetic Integrity
Life Whisperer produces two confidence scores from 0 to 10, one indicating how confident the AI-based algorithm is in the likelihood that an embryo will lead to pregnancy and the other indicating the confidence that the embryo is euploid.**
Figure 3. What Does Your Report Tell You About Your Embryo Status
**The Life Whisperer Viability confidence score represents the likelihood that the embryo may or may not result in a successful clinical pregnancy. It does not represent the probability of a live birth. The performance of Life Whisperer Viability does not take into account any patient-specific factors that may influence clinical outcome. The Life Whisperer Genetics confidence score reflects the confidence that the embryo may or may not be euploid in vitro on Day 5 of development. It does not represent the likelihood of euploidy in utero nor at birth. Life Whisperer Genetics is not a substitute for prenatal testing. Prenatal testing is advised to confirm the genetic status of the fetus should a pregnancy occur.
Customer Testimonial
"IVF labs across the globe are constantly challenged to best identify embryos which will successfully develop into healthy children. Used as a non-invasive adjunct tool to help select embryos with the highest potential for success, the Life Whisperer AI-based technology will certainly assist in this critical selection process."
- Matthew "Tex" VerMilyea PhD, HCLD/CC (ABB), Vice President of Scientific Advancement – Ovation Fertility; Scientific Director – Texas Fertility Centers; Laboratory and Operations Director – Ovation Fertility Austin
How Life Whisperer Works
Life Whisperer harnesses an artificial intelligence algorithm to deliver a stress-free method of grading embryos. Images are dragged and dropped into the app with ease, analyzed, and ranked in order of most likely to least likely to result in clinical pregnancy in under one minute. Each embryo is assigned a confidence score of 0-10, with 10 indicating the highest quality embryo with the greatest likelihood of clinical pregnancy and embryos being euploid.
References:
- Diakiw SM, Hall JMM, VerMilyea M, et al. An artificial intelligence model correlated with morphological and genetic features of blastocyst quality improves ranking of viable embryos. RBMO. 2022;45(6): 1105-1117
- Diakiw SM, Hall JMM, VerMilyea MD, et al. Development of an artificial intelligence model for predicting the likelihood of human embryo euploidy based on blastocyst images from multiple imaging systems during IVF. Hum Reprod. 2022;37(8):1746-1759. doi:10.1093/humrep/deac131
Contact Us to Learn More
Interested in learning more about Life Whisperer? Fill out this form and a sales representative will reach out with more information.
Life Whisperer is a software application for assessment of embryo images, intended to be used for clinical decision support to aid in the selection of embryos during in vitro fertilization (IVF) procedures. Not intended to be used as direct diagnostics. Any treatment decisions should be made in combination with other methods of embryo evaluation, and the user’s own expert opinion, according to institutional procedure.
Life Whisperer Genetics is not to be used as a substitute for standard embryo evaluation methods. Additional assessments such as conventional morphological evaluation should be conducted, and Life Whisperer Genetics used solely to provide additional information on the likelihood of embryo euploidy. Life Whisperer Genetics is not to be used as direct diagnostics - confirmatory PGT-A or other genetic testing methods should be conducted as warranted. The healthcare professional should make the final informed assessment regarding additional testing, transfer, cryopreservation, or any other decision with respect to the embryo or patient.
Available from FUJIFILM Irvine Scientific, sole worldwide distributor, in select regions. Life Whisperer is not authorized for sale in the US.
Customer Testimonial
"IVF labs across the globe are constantly challenged to best identify embryos which will successfully develop into healthy children. Used as a non-invasive adjunct tool to help select embryos with the highest potential for success, the Life Whisperer AI technology will certainly assist in this critical selection process." - Matthew "Tex" VerMilyea PhD, HCLD/CC (ABB), Vice President of Scientific Advancement – Ovation Fertility; Scientific Director – Texas Fertility Centers; Laboratory and Operations Director – Ovation Fertility Austin
