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Recombinant Rat IL-1 β

In stock
Catalog ID
300-30
Size Stock SKU Unit Price Qty
10 µg In Stock 300-30-10UG
$183.00
    100 µg In Stock 300-30-100UG
    $705.00
      500 µg Inquire for Availability 300-30-500UG
      $3,503.00
        1 mg Inquire for Availability 300-30-1MG
        $5,839.00
          reset
          Details

          Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

          Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

          Instructions

          Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

          Technical Specifications

          Alternate Names Catabolin, LAF, EP, LEM, MCF
          Accession Number Q63264
          Source Genetically modified E.coli
          Predicted Molecular Mass Monomer, 17.4 kDa (153 aa)
          AA Sequence MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMSFVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGNSNG RDIVDFTMEP VSS
          Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
          Product Reconstitution Sterile water at 0.1 mg/mL
          Country of Origin USA

           

          Specification* Method of Determination Acceptance Criteria
          Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
          Endotoxin Kinetic LAL ≤ 0.1 EU/µg
          Biological Activity (ED50) No biological activity data is available at this time No biological activity data is available at this time

           

          *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

          IL-1 beta

          Specifications

          Storage
          At or below -20°C
          Shelf Life
          12 months from date of receipt when stored at -20°C to-80°C as supplied.
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