Recombinant Human TNFR-1

In stock

Catalog ID

100-35

Size	Stock	SKU	Unit Price
5 µg	In Stock	100-35-5UG	$73.00
20 µg	In Stock	100-35-20UG	$183.00
100 µg	In Stock	100-35-100UG	$457.00
500 µg	In Stock	100-35-500UG	$1,971.00
1 mg	In Stock	100-35-1MG	$3,284.00

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Details

Tumor necrosis factor receptor type 1 (TNFR1) is expressed in most tissues and is activated by soluble and membrane-bound tumor necrosis factor alpha (TNFa). TNFR1 activates NF-κB and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis, and inhibit viral replication.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	TNFAR, CD120a, TNFRSF1A, TNFR55
Accession Number	P19438
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 18.3 kDa (162 aa)
AA Sequence	MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQI EN
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 1 EU/µg
Biological Activity (ED₅₀)	Neutralization of human TNF alpha induced L929 cell cytolysis	≤ 100 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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