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Recombinant Human TNFR-1

In stock
Catalog ID
100-35
Size Stock SKU Unit Price Qty
5 µg In Stock 100-35-5UG
$73.00
    20 µg In Stock 100-35-20UG
    $183.00
      100 µg In Stock 100-35-100UG
      $457.00
        500 µg In Stock 100-35-500UG
        $1,971.00
          1 mg In Stock 100-35-1MG
          $3,284.00
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            Details

            Tumor necrosis factor receptor type 1 (TNFR1) is expressed in most tissues and is activated by soluble and membrane-bound tumor necrosis factor alpha (TNFa). TNFR1 activates NF-κB and MAPK pathways to induce inflammation, promote apoptotic cell death, inhibit tumorigenesis, and inhibit viral replication.

            Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

            Instructions

            Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

            Technical Specifications

            Alternate Names TNFAR, CD120a, TNFRSF1A, TNFR55
            Accession Number P19438
            Source Genetically modified E.coli
            Predicted Molecular Mass Monomer, 18.3 kDa (162 aa)
            AA Sequence MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQI EN
            Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
            Product Reconstitution Sterile water at 0.1 mg/mL
            Country of Origin USA

             

            Specification* Method of Determination Acceptance Criteria
            Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
            Endotoxin Kinetic LAL ≤ 1 EU/µg
            Biological Activity (ED50) Neutralization of human TNF alpha induced L929 cell cytolysis ≤ 100 ng/mL

             

            *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

            Specifications

            Storage
            At or below -20°C
            Shelf Life
            12 months from date of receipt when stored at -20°C to-80°C as supplied.
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