Recombinant Human OSM

In stock

Catalog ID

100-56

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-56-10UG	$183.00
100 µg	Inquire for Availability	100-56-100UG	$705.00
500 µg	Inquire for Availability	100-56-500UG	$3,503.00
1 mg	Inquire for Availability	100-56-1MG	$5,839.00
10 µg (Animal-Free)	In Stock	100-56AF-10UG	$200.00
100 µg (Animal-Free)	In Stock	100-56AF-100UG	$773.00
500 µg (Animal-Free)	Inquire for Availability	100-56AF-500UG	$3,857.00
1 mg (Animal-Free)	Inquire for Availability	100-56AF-1MG	$6,422.00

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Details

Oncostatin M is a cytokine that is produced by macrophages, dendritic cells, and T lymphocytes during inflammatory events. The Type-I and Type-II Oncostatin M receptors are located on the cell surface of endothelial and tumor cells, contain the glycoprotein 130 (gp130) subunit, and activate the JAK/STAT signaling pathway. Oncostatin M functions to inhibit tumor cell proliferation, induce liver stem cell maturation, regulate cytokine production during hematopoiesis and inflammation, stimulate bone formation, and promote nervous system development.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Onc-M
Accession Number	P13725
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 23.8 kDa (210 aa)
AA Sequence	MAAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLGCVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRFLHGYHRFMHS VGRVFSKWGE SPNRSRRHSP HQALRKGVRR
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 1 EU/µg
Biological Activity (ED₅₀)	TF-1 cell proliferation	≤ 4 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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