Recombinant Human MCP-1 / CCL2
Monocyte chemotactic protein 1 (MCP-1), also known as CCL2, is produced by injured or infected tissues. MCP-1 signals through the CCR2 and CCR4 G protein-coupled receptors to recruit memory T cells, monocytes, and dendritic cells to sites of inflammation.
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Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.
|Alternate Names||CCL2, JE, MCAF|
|Source||Genetically modified E.coli|
|Predicted Molecular Mass||Monomer, 8.7 kDa (76 aa)|
|AA Sequence||QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT|
|Formulation||Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)|
|Product Reconstitution||Sterile water at 0.1 mg/mL|
|Country of Origin||USA|
|Specification*||Method of Determination||Acceptance Criteria|
|Purity||Reducing and Non-Reducing SDS PAGE||≥ 95%|
|Endotoxin||Kinetic LAL||≤ 0.1 EU/µg|
|Biological Activity (ED50)||THP-1 chemotaxis||≤ 100 ng/mL|
*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.