Recombinant Human TGF-α

In stock

Catalog ID

100-209

Size	Stock	SKU	Unit Price
25 µg	In Stock	100-209-25UG	$73.00
100 µg	Inquire for Availability	100-209-100UG	$183.00
250 µg	Inquire for Availability	100-209-250UG	$395.00
500 µg	Inquire for Availability	100-209-500UG	$729.00
1 mg	Inquire for Availability	100-209-1MG	$1,278.00
25 µg (Animal-Free)	In Stock	100-209AF-25UG	$79.00
100 µg (Animal-Free)	In Stock	100-209AF-100UG	$200.00
250 µg (Animal-Free)	In Stock	100-209AF-250UG	$438.00
500 µg (Animal-Free)	Inquire for Availability	100-209AF-500UG	$803.00
1 mg (Animal-Free)	Inquire for Availability	100-209AF-1MG	$1,404.00

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Details

Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signaling. TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation. In the gastric mucosa, TGF-α production inhibits gastric acid secretion and therefore plays a central role in the pathogenesis of the stomach syndrome Ménétrier’s disease. TGF-α is also produced in adult macrophages, brain cells, keratinocytes, and is widely expressed in cancer cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	TGF-alpha, EGF-like TGF, ETGF, TGFA, TGF type 1
Accession Number	P01135
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 5.6 kDa (50 aa)
AA Sequence	VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Formulation	Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	BALB/c 3T3 Cell Proliferation	≤ 2 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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