Recombinant Human PTN

In stock

Catalog ID

100-55

Size	Stock	SKU	Unit Price
5 µg	Inquire for Availability	100-55-5UG	$73.00
20 µg	In Stock	100-55-20UG	$183.00
100 µg	Inquire for Availability	100-55-100UG	$457.00
500 µg	Inquire for Availability	100-55-500UG	$1,971.00
1 mg	Inquire for Availability	100-55-1MG	$3,284.00
5 µg (Animal-Free)	Inquire for Availability	100-55AF-5UG	$79.00
20 µg (Animal-Free)	Inquire for Availability	100-55AF-20UG	$200.00
100 µg (Animal-Free)	Inquire for Availability	100-55AF-100UG	$504.00
500 µg (Animal-Free)	Inquire for Availability	100-55AF-500UG	$2,165.00
1 mg (Animal-Free)	Inquire for Availability	100-55AF-1MG	$3,613.00

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Details

Pleiotrophin (PTN) is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. PTN is made by many tissues, but is predominantly secreted by nervous tissue during development. PTN induces neurite outgrowth and is involved in tumor growth and metastasis. PTN binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection. PNT also binds the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	HBBM, HBGF-8, NEGF1, HARP
Accession Number	P21246
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 15.4 kDa (137 aa)
AA Sequence	MGKKEKPEKK VKKSDCGEWQ WSVCVPTSGD CGLGTREGTR TGAECKQTMK TQRCKIPCNW KKQFGAECKY QFQAWGECDL NTALKTRTGS LKRALHNAEC QKTVTISKPC GKLTKPKPQA ESKKKKKEGK KQEKMLD
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	No biological activity data is available at this time	No biological activity data is available at this time

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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