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Recombinant Human PDGF-AA

In stock
Catalog ID
100-16
Size Stock SKU Unit Price Qty
10 µg Inquire for Availability 100-16-10UG
$183.00
    100 µg In Stock 100-16-100UG
    $517.00
      500 µg In Stock 100-16-500UG
      $2,554.00
        1 mg Inquire for Availability 100-16-1MG
        $4,258.00
          10 µg (Animal-Free) Inquire for Availability 100-16AF-10UG
          $200.00
            100 µg (Animal-Free) In Stock 100-16AF-100UG
            $566.00
              500 µg (Animal-Free) Inquire for Availability 100-16AF-500UG
              $2,811.00
                1 mg (Animal-Free) Inquire for Availability 100-16AF-1MG
                $4,683.00
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                  Details

                  Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.

                  Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

                  Instructions

                  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

                  Technical Specifications

                  Alternate Names GDGF, ODGF
                  Accession Number P04085
                  Source Genetically modified E.coli
                  Predicted Molecular Mass Dimer, 14.4/28.9 kDa (126/252 aa)
                  AA Sequence MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT
                  Formulation Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
                  Product Reconstitution Sterile water at 0.1 mg/mL
                  Country of Origin USA

                   

                  Specification* Method of Determination Acceptance Criteria
                  Purity Reducing and Non-Reducing SDS-PAGE ≥ 95%
                  Endotoxin Kinetic LAL ≤ 0.1 EU/µg
                  Biological Activity (ED50) NR6R-3T3 cell proliferation ≤ 50 ng/mL; ≥ 2.0 x 104 units/mg

                   

                  *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

                  Specifications

                  Storage
                  At or below -20°C
                  Shelf Life
                  12 months from date of receipt when stored at -20°C to -80°C as supplied.
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