Recombinant Human Myostatin

In stock

Catalog ID

100-22

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-22-10UG	$183.00
100 µg	Inquire for Availability	100-22-100UG	$705.00
500 µg	Inquire for Availability	100-22-500UG	$3,503.00
1 mg	In Stock	100-22-1MG	$5,839.00
10 µg (Animal-Free)	In Stock	100-22AF-10UG	$200.00
100 µg (Animal-Free)	In Stock	100-22AF-100UG	$773.00
500 µg (Animal-Free)	Inquire for Availability	100-22AF-500UG	$3,857.00
1 mg (Animal-Free)	Inquire for Availability	100-22AF-1MG	$6,422.00

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Details

Myostatin, also known as GDF-8, is a conserved member of the TGF-beta superfamily. Myostatin is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA or ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.

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Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	GDF-8, MSTN
Accession Number	O14793
Source	Genetically modified E.coli
Predicted Molecular Mass	Dimer, 12.4/24.8 kDa (109/218 aa)
AA Sequence	DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution	Sterile 20 mM HCl at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	MPC-11 cell cytotoxicity	≤ 50 ng/ml; ≥ 2.0 x 10⁴ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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