Recombinant Human / Mouse / Rat GDF-11

In stock

Catalog ID

800-04

Size	Stock	SKU	Unit Price
5 µg	In Stock	800-04-5UG	$73.00
20 µg	In Stock	800-04-20UG	$183.00
100 µg	In Stock	800-04-100UG	$517.00
500 µg	Inquire for Availability	800-04-500UG	$2,554.00
1 mg	Inquire for Availability	800-04-1MG	$4,258.00
5 µg (Animal-Free)	In Stock	800-04AF-5UG	$79.00
20 µg (Animal-Free)	In Stock	800-04AF-20UG	$200.00
100 µg (Animal-Free)	In Stock	800-04AF-100UG	$566.00
500 µg (Animal-Free)	Inquire for Availability	800-04AF-500UG	$2,811.00
1 mg (Animal-Free)	Inquire for Availability	800-04AF-1MG	$4,683.00

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Details

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	BMP-11
Accession Number	O95390/Q9Z1W4/Q9Z217
Source	Genetically modified E.coli
Predicted Molecular Mass	Dimer, 12.5/24.9 kDa (109/218 aa)
AA Sequence	NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution	Sterile 10 mM HCl at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	Alkaline phosphatase activity in ATDC5 cells	≤ 100 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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