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Recombinant Human / Mouse / Rat GDF-11

In stock
Catalog ID
800-04
Size Stock SKU Unit Price Qty
5 µg Inquire for Availability 800-04-5UG
$73.00
5 µg (Animal-Free) In Stock 800-04AF-5UG
$79.00
20 µg In Stock 800-04-20UG
$183.00
20 µg (Animal-Free) In Stock 800-04AF-20UG
$200.00
100 µg In Stock 800-04-100UG
$517.00
100 µg (Animal-Free) In Stock 800-04AF-100UG
$566.00
500 µg Inquire for Availability 800-04-500UG
$2,554.00
500 µg (Animal-Free) Inquire for Availability 800-04AF-500UG
$2,811.00
1 mg Inquire for Availability 800-04-1MG
$4,258.00
1 mg (Animal-Free) Inquire for Availability 800-04AF-1MG
$4,683.00
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Details

Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names BMP-11
Accession Number O95390/Q9Z1W4/Q9Z217
Source Genetically modified E.coli
Predicted Molecular Mass Dimer, 12.5/24.9 kDa (109/218 aa)
AA Sequence NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Formulation Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution Sterile 10 mM HCl at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
Endotoxin Kinetic LAL ≤ 0.1 EU/µg
Biological Activity (ED50) Alkaline phosphatase activity in ATDC5 cells ≤ 100 ng/mL

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to -80°C as supplied.
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