Recombinant Human / Mouse / Rat Activin-A

In stock

Catalog ID

800-01

Size	Stock	SKU	Unit Price
10 µg	In Stock	800-01-10UG	$176.00
10 µg (Animal-Free)	In Stock	800-01AF-10UG	$192.00
100 µg	Inquire for Availability	800-01-100UG	$567.00
100 µg (Animal-Free)	In Stock	800-01AF-100UG	$626.00
500 µg	In Stock	800-01-500UG	$2,456.00
500 µg (Animal-Free)	In Stock	800-01AF-500UG	$2,703.00
1 mg	In Stock	800-01-1MG	$4,094.00
1 mg (Animal-Free)	In Stock	800-01AF-1MG	$4,503.00

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Details

Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin βA chains. Cleavage of the N-terminal propeptide renders the Activin protein biologically active. Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Inhibin beta-1, FRP, FSH-releasing protein
Accession Number	P08476/Q04998/P18331
Source	Genetically modified E.coli
Predicted Molecular Mass	Dimer, 13.1/26.2 kDa (117/234 aa)
AA Sequence	MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	Cytotoxicity of MPC-11 cells	≤ 10 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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