Recombinant Human / Mouse NT-3

In stock

Catalog ID

800-06

Size	Stock	SKU	Unit Price
10 µg	In Stock	800-06-10UG	$183.00
100 µg	In Stock	800-06-100UG	$705.00
500 µg	In Stock	800-06-500UG	$3,503.00
1 mg	In Stock	800-06-1MG	$5,839.00
10 µg (Animal-Free)	In Stock	800-06AF-10UG	$200.00
100 µg (Animal-Free)	In Stock	800-06AF-100UG	$779.00
500 µg (Animal-Free)	Inquire for Availability	800-06AF-500UG	$3,857.00
1 mg (Animal-Free)	In Stock	800-06AF-1MG	$6,422.00

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Details

Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Neurotrophin 3, Nerve growth factor 2 (NGF-2), HGNF, NT3, Neurotrophic Factor
Accession Number	P20783/P20181
Source	Genetically modified E.coli
Predicted Molecular Mass	Dimer, 13.8/27.5 kDa (120/240 aa)
AA Sequence	MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
Formulation	Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	Proliferation of a neuroblastoma cell line stably expressing TrkB (BR6)	≤ 20 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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