Recombinant Human LIF

In stock

Catalog ID

100-47

Size	Stock	SKU	Unit Price
5 µg	In Stock	100-47-5UG	$73.00
25 µg	Inquire for Availability	100-47-25UG	$183.00
100 µg	In Stock	100-47-100UG	$457.00
500 µg	Inquire for Availability	100-47-500UG	$1,825.00
1 mg	Inquire for Availability	100-47-1MG	$3,041.00
5 µg (Animal-Free)	In Stock	100-47AF-5UG	$79.00
25 µg (Animal-Free)	Inquire for Availability	100-47AF-25UG	$200.00
100 µg (Animal-Free)	In Stock	100-47AF-100UG	$504.00
500 µg (Animal-Free)	Inquire for Availability	100-47AF-500UG	$2,008.00
1 mg (Animal-Free)	Inquire for Availability	100-47AF-1MG	$3,346.00

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Details

Leukemia inhibitory factor (LIF) is a member of the interleukin 6 (IL-6) family that is made by a variety of adult and embryonic tissues. LIF signals through the glycoprotein 130 (gp130)/LIF receptor (LIFR) heterodimer to activate STAT3 and MAPK signaling. LIF functions during hematopoietic differentiation, neuronal cell differentiation, kidney development, and inflammatory processes. Human LIF may also be an important factor during human embryonic stem cell (hESC) self-renewal, pluripotency, and embryonic implantation.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Leukocyte Inhibitory Factor
Accession Number	P15018
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 19.8 kDa (181 aa)
AA Sequence	MSPLPITPVN ATCAIRHPCH NNLMNQIRSQ LAQLNGSANA LFILYYTAQG EPFPNNLDKL CGPNVTDFPP FHANGTEKAK LVELYRIVVY LGTSLGNITR DQKILNPSAL SLHSKLNATA DILRGLLSNV LCRLCSKYHV GHVDVTYGPD TSGKDVFQKK KLGCQLLGKY KQIIAVLAQA F
Formulation	Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution	Sterile 10 mM acetic acid at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	TF-1 cell proliferation	≤ 0.2 ng/mL; ≥ 5.0 x 10⁶ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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