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Recombinant Human IL-1α / IL-1F1

In stock
Catalog ID
100-173
Size Stock SKU Unit Price Qty
10 µg Inquire for Availability 100-173-10UG
$183.00
    100 µg Inquire for Availability 100-173-100UG
    $705.00
      500 µg Inquire for Availability 100-173-500UG
      $2,554.00
        1 mg Inquire for Availability 100-173-1MG
        $4,258.00
          10 µg (Animal-Free) In Stock 100-173AF-10UG
          $200.00
            100 µg (Animal-Free) Inquire for Availability 100-173AF-100UG
            $779.00
              500 µg (Animal-Free) Inquire for Availability 100-173AF-500UG
              $2,811.00
                1 mg (Animal-Free) Inquire for Availability 100-173AF-1MG
                $4,683.00
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                  Details

                  Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

                  Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

                  Instructions

                  Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

                  Technical Specifications

                  Alternate Names IL-1F1, FAF, BAF, LEM, LAF
                  Accession Number P01583
                  Source Genetically modified E.coli
                  Predicted Molecular Mass Monomer, 18 kDa (159 aa)
                  AA Sequence SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
                  Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
                  Product Reconstitution Sterile water at 0.1 mg/mL
                  Country of Origin USA

                   

                  Specification* Method of Determination Acceptance Criteria
                  Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
                  Endotoxin Kinetic LAL ≤ 1 EU/µg
                  Biological Activity (ED50) D10.G4.1 cell proliferation ≤ 0.05 ng/mL; ≥ 2.0 x 107 units/mg

                   

                  *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

                  IL-1alpha IL-1 alpha

                  Specifications

                  Storage
                  At or below -20°C
                  Shelf Life
                  12 months from date of receipt when stored at -20°C to-80°C as supplied.
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