Recombinant Human FGF-7 / KGF

In stock

Catalog ID

100-187

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-187-10UG	$183.00
100 µg	In Stock	100-187-100UG	$705.00
500 µg	Inquire for Availability	100-187-500UG	$3,503.00
1 mg	In Stock	100-187-1MG	$5,839.00
10 µg (Animal-Free)	Inquire for Availability	100-187AF-10UG	$200.00
100 µg (Animal-Free)	In Stock	100-187AF-100UG	$773.00
500 µg (Animal-Free)	In Stock	100-187AF-500UG	$3,857.00
1 mg (Animal-Free)	In Stock	100-187AF-1MG	$6,422.00

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Details

Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectodermal ridge during limb development.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	KGF
Accession Number	P21781
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 19 kDa (164 aa)
AA Sequence	MACNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT
Formulation	Lyophilized from a 0.2 µm filtered solution containing 20 mM sodium phosphate, 0.5 M sodium chloride, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL (reconstitution at concentrations > 0.1 mg/mL may result in a precipitate)
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 90%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	4MBr-5 cell proliferation	≤ 60 ng/mL; ≥ 1.7 x 10⁴ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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