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Y-27632, MF

In stock
Catalog ID
259-00613, 257-00614
Size Stock SKU Unit Price Qty
5 mg Inquire for Availability 259-00613
$605.00
    25 mg In Stock 257-00614
    $2,420.00
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      Details

      This product is registered in the Drug Master File in Japan.

      It is a selective and potent inhibitor of ROCK (Rho-associated coiled-coil forming kinase/Rho binding kinase).

      Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling (Ki = 140 nmol/L p160ROCK). This product has been reported to suppress death of human ES cells and human iPS cells at the time of cell dispersion, and also improve viability of the cells after cryopreservation.
      [ROCK : Rho-associated coiled-coil forming kinase]

      This product is for research use only. Do not administer it to human.

      Applications/Properties

      For Cell Culture

      Manufacturer: FUJIFILM Wako Pure Chemical Corporation
      Specification Assay: 98.0+% (HPLC)
      CAS RN: 331752-47-7
      Molecular Formula: C14H21N3O・2HCl・H2O
      Molecular Weight: 338.27
      GHS: Warning
      Precautions for Use: Packed on inactive gas
      Appearance: White - pale yellow, crystalline powder - powder
      Boiling Point: About 85°C
      Specific Rotation: +2.0 - +10.0°(D/20°C)(c=1.0,CH3OH)
      Purity: Bacterial endotoxins : <0.25 EU/mg
      Alias: (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide Dihydrochloride Monohydrate
      Preparation:
      Solubility Data for Y-27632 dihydrochloride

      C14H21N3O・2HCl・H2O = 338.27

        Solvent Conc. mg/mL Conc. mmol/L
      Solubility Water 10 mg/mL 29.56 mmol/L
        Ethanol 10 mg/mL 29.56 mmol/L
      Preparing Stock Solutions

      C14H21N3O・2HCl・H2O = 338.27

      Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
      1 mmol/L 2.956 mL 14.781 mL 29.562 mL
      5 mmol/L 0.591 mL 2.956 mL 5.912 mL
      10 mmol/L 0.296 mL 1.478 mL 2.956 mL
      50 mmol/L 0.059 mL 0.296 mL 0.591 mL
      Y-27632 Comparison Chart
        ICH-Q7 ISO9001 Sterility
      test
      Viable
      count
      test
      Animal-
      derived-
      free
      Bacterial
      Endotoxin
      test
      Mycoplasma
      test
      Powder/
      Liquid
      References*
      Y-27632 (GMP-compliant)** - Powder
      Y-27632, MF*** - - Powder Link
      CultureSure Y-27632 - - - Powder Link
      CultureSure 10mmol/L
      Y-27632 Solution,
      Animal-derived-free
      - -

      Liquid

      Sterilized with filter

      Link

      * Click to move to the PubMed Central search results.
      ** This product is complied with ICH-Q7 (GMP for APIs) as a raw material for commercial production of regenerative medicine products.
      *** The manufacturing process and analytical procedure are validated.

       

      Made by FUJIFILM Wako Pure Chemical Corporation and distributed by FUJIFILM Irvine Scientific 

      • For research use or further manufacturing use only. Not for use in diagnostic procedures. 
      • Product content may differ from the actual image due to minor specification changes etc. 
      • If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different. 

      Specifications

      Storage
      Keep at -20°C
      Product Sheets
      Product Specifications
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