Recombinant Human IL-21

In stock

Catalog ID

100-90

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-90-10UG	$183.00
100 µg	In Stock	100-90-100UG	$705.00
500 µg	In Stock	100-90-500UG	$3,503.00
1 mg	Inquire for Availability	100-90-1MG	$5,839.00
10 µg (Animal-Free)	In Stock	100-90AF-10UG	$200.00
100 µg (Animal-Free)	In Stock	100-90AF-100UG	$773.00
500 µg (Animal-Free)	In Stock	100-90AF-500UG	$3,857.00
1 mg (Animal-Free)	Inquire for Availability	100-90AF-1MG	$6,422.00

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Details

Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	None
Accession Number	Q9HBE4
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 15.4 kDa (132 aa)
AA Sequence	MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 97%
Endotoxin	Kinetic LAL	≤ 1 EU/µg
Biological Activity (ED₅₀)	B9 cell proliferation	≤ 5 ng/mL; ≥ 2.0 x 10⁵ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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