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Recombinant Human IL-21

In stock
Catalog ID
100-90
Size Stock SKU Unit Price Qty
10 µg Inquire for Availability 100-90-10UG
$183.00
10 µg (Animal-Free) In Stock 100-90AF-10UG
$200.00
100 µg In Stock 100-90-100UG
$705.00
100 µg (Animal-Free) In Stock 100-90AF-100UG
$773.00
500 µg In Stock 100-90-500UG
$3,503.00
500 µg (Animal-Free) In Stock 100-90AF-500UG
$3,857.00
1 mg Inquire for Availability 100-90-1MG
$5,839.00
1 mg (Animal-Free) Inquire for Availability 100-90AF-1MG
$6,422.00
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Details

Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names None
Accession Number Q9HBE4
Source Genetically modified E.coli
Predicted Molecular Mass Monomer, 15.4 kDa (132 aa)
AA Sequence MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution Sterile water at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 97%
Endotoxin Kinetic LAL ≤ 1 EU/µg
Biological Activity (ED50) B9 cell proliferation ≤ 5 ng/mL; ≥ 2.0 x 105 units/mg

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to-80°C as supplied.
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