Recombinant Human IFN-γ

In stock

Catalog ID

100-77

Size	Stock	SKU	Unit Price
20 µg	In Stock	100-77-20UG	$73.00
100 µg	In Stock	100-77-100UG	$183.00
250 µg	In Stock	100-77-250UG	$419.00
500 µg	Inquire for Availability	100-77-500UG	$700.00
1 mg	Inquire for Availability	100-77-1MG	$1,217.00
20 µg (Animal-Free)	In Stock	100-77AF-20UG	$79.00
100 µg (Animal-Free)	In Stock	100-77AF-100UG	$200.00
250 µg (Animal-Free)	Inquire for Availability	100-77AF-250UG	$462.00
500 µg (Animal-Free)	Inquire for Availability	100-77AF-500UG	$766.00
1 mg (Animal-Free)	In Stock	100-77AF-1MG	$1,338.00

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Details

Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFN-γ is not cross-reactive with mouse IFN-γ.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. If a precipitate is observed, centrifuge the solution thoroughly and use only the soluble fraction (removing it from the precipitate). A 10% overfill has been added to compensate for any loss of protein in the precipitate. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Type II interferon, T cell interferon, Immune Interferon, MAF
Accession Number	P01579
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 16.9 kDa (144 aa)
AA Sequence	MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	Viral challenge assay using EMC virus on A549 cells	≤ 0.75 ng/mL; ≥ 1.3 x 10⁶ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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