Join Our Mailing List Today!

NOTICE: Online ordering will be disabled 1/27-2/3. Learn More.

Recombinant Human Follistatin

In stock
Catalog ID
100-41
Size Stock SKU Unit Price Qty
5 µg In Stock 100-41-5UG
$73.00
20 µg In Stock 100-41-20UG
$183.00
100 µg In Stock 100-41-100UG
$705.00
500 µg Inquire for Availability 100-41-500UG
$3,503.00
1 mg Inquire for Availability 100-41-1MG
$5,839.00
reset
Details

Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1. Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names FS, activin-binding protein, FSH-suppressing protein (FSP)
Accession Number P19883
Source Genetically modified E.coli
Predicted Molecular Mass Monomer, 31.7 kDa (289 aa)
AA Sequence MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRMNKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPEPASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DFKVGRGRCS LCDELCPDSK SDEPVCASDNATYASECAMK EAACSSGVLL EVKHSGSCN
Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
Product Reconstitution Sterile water at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
Endotoxin Kinetic LAL ≤ 0.1 EU/µg
Biological Activity (ED50) Neutralization of Human Activin A induced cytotoxicity of MPC-11 cells ≤ 200 ng/mL; ≥ 5.0 x 103 units/mg

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to-80°C as supplied.
© 2024 FUJIFILM Irvine Scientific. All rights reserved.