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Recombinant Human IL-1β

In stock
Catalog ID
100-167
Size Stock SKU Unit Price Qty
10 µg In Stock 100-167-10UG
$183.00
10 µg (Animal-Free) In Stock 100-167AF-10UG
$200.00
100 µg In Stock 100-167-100UG
$529.00
100 µg (Animal-Free) In Stock 100-167AF-100UG
$577.00
500 µg In Stock 100-167-500UG
$2,627.00
500 µg (Animal-Free) Inquire for Availability 100-167AF-500UG
$2,889.00
1 mg In Stock 100-167-1MG
$4,379.00
1 mg (Animal-Free) In Stock 100-167AF-1MG
$4,817.00
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Details

Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping pro-inflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock. 

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names Catabolin, LAF, EP, LEM, MCF
Accession Number P01584
Source Genetically modified E.coli
Predicted Molecular Mass Monomer, 17.5 kDa (154 aa)
AA Sequence MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution Sterile water at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
Endotoxin Kinetic LAL ≤ 1 EU/µg
Biological Activity (ED50) D10S cell proliferation ≤ 0.012 ng/mL; ≥ 8.3 x 107 units/mg

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

IL-1beta IL-1 beta

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to -80°C as supplied.
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