Recombinant Human IL-10

In stock

Catalog ID

100-83

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-83-10UG	$183.00
100 µg	In Stock	100-83-100UG	$705.00
500 µg	In Stock	100-83-500UG	$3,503.00
1 mg	In Stock	100-83-1MG	$5,839.00
10 µg (Animal-Free)	In Stock	100-83AF-10UG	$200.00
100 µg (Animal-Free)	In Stock	100-83AF-100UG	$773.00
500 µg (Animal-Free)	Inquire for Availability	100-83AF-500UG	$3,857.00
1 mg (Animal-Free)	Inquire for Availability	100-83AF-1MG	$6,422.00

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Details

Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. Human IL-10 can act on murine cells, while murine IL-10 is not active on human cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	B-TCGF, CSIF, TGIF
Accession Number	P22301
Source	Genetically modified E.coli
Predicted Molecular Mass	Noncovalent Homodimer, 18.8 kDa (161 aa)
AA Sequence	MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 97%
Endotoxin	Kinetic LAL	≤ 1 EU/µg
Biological Activity (ED₅₀)	MC/9 cell Proliferation	≤ 5 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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