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Recombinant Human G-CSF

In stock
Catalog ID
100-72
Size Stock SKU Unit Price Qty
10 µg In Stock 100-72-10UG
$183.00
10 µg (Animal-Free) In Stock 100-72AF-10UG
$200.00
100 µg In Stock 100-72-100UG
$590.00
100 µg (Animal-Free) In Stock 100-72AF-100UG
$651.00
500 µg In Stock 100-72-500UG
$2,554.00
500 µg (Animal-Free) Inquire for Availability 100-72AF-500UG
$2,811.00
1 mg In Stock 100-72-1MG
$4,258.00
1 mg (Animal-Free) In Stock 100-72AF-1MG
$4,683.00
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Details

Granulocyte-colony stimulating factor (G-CSF) is a cytokine that functions as a potent inducer of neutrophilic granulocyte proliferation, terminal differentiation, and activation. G-CSF synthesis occurs in monocyte, macrophage, epithelial, endothelial, and fibroblast cells after activation by bacterial endotoxins, tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), or interleukin 17 (IL-17). The functional activity of G-CSF is mediated through the granulocyte colony-stimulating factor receptor (G-CSF-R) to activate JAK/STAT and MAPK signal transduction pathways. G-CSF also promotes neurogenesis and inhibits neuronal apoptosis. Human and mouse G-CSF proteins are cross-reactive.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names CSF-3, MGI-1G, GM-CSFβ, pluripoietin
Accession Number P09919
Source Genetically modified E.coli
Predicted Molecular Mass Monomer, 18.8 kDa (175 aa)
AA Sequence MTPLGPASSL PQSFLLKCLE QVRKIQGDGA ALQEKLCATY KLCHPEELVL LGHSLGIPWA PLSSCPSQAL QLAGCLSQLH SGLFLYQGLL QALEGISPEL GPTLDTLQLD VADFATTIWQ QMEELGMAPA LQPTQGAMPA FASAFQRRAG GVLVASHLQS FLEVSYRVLR HLAQP
Formulation Lyophilized from a 0.2 µm filtered solution containing 20 mM acetic acid, 50 mM sodium chloride.
Product Reconstitution Sterile water at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
Endotoxin Kinetic LAL ≤ 0.1 EU/µg
Biological Activity (ED50) NFS-60 cell proliferation ≤ 0.060 ng/mL

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to -80°C as supplied.
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