Recombinant Human CD40-Ligand

In stock

Catalog ID

100-25

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-25-10UG	$73.00
50 µg	In Stock	100-25-50UG	$183.00
100 µg	In Stock	100-25-100UG	$330.00
500 µg	In Stock	100-25-500UG	$839.00
1 mg	In Stock	100-25-1MG	$1,460.00
10 µg (Animal-Free)	In Stock	100-25AF-10UG	$79.00
50 µg (Animal-Free)	In Stock	100-25AF-50UG	$200.00
100 µg (Animal-Free)	In Stock	100-25AF-100UG	$359.00
500 µg (Animal-Free)	Inquire for Availability	100-25AF-500UG	$925.00
1 mg (Animal-Free)	In Stock	100-25AF-1MG	$1,607.00

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Details

CD40-Ligand, or CD154, is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40-Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40-Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40-Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40-Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	TNFSF5, TRAP, CD154, gp39, T-BAM
Accession Number	P29965
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 16.3 kDa (149 aa)
AA Sequence	MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LCLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	Activity of HEK-Blue CD40L cells	≤ 50 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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