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Recombinant Mouse IL-1α / IL-1F1

In stock
Catalog ID
200-87
Size Stock SKU Unit Price Qty
5 µg In Stock 200-87-5UG
$73.00
    20 µg In Stock 200-87-20UG
    $183.00
      100 µg In Stock 200-87-100UG
      $822.00
        500 µg Inquire for Availability 200-87-500UG
        $2,554.00
          1 mg Inquire for Availability 200-87-1MG
          $4,258.00
            5 µg (Animal-Free) Inquire for Availability 200-87AF-5UG
            $79.00
              20 µg (Animal-Free) In Stock 200-87AF-20UG
              $200.00
                100 µg (Animal-Free) Inquire for Availability 200-87AF-100UG
                $905.00
                  500 µg (Animal-Free) Inquire for Availability 200-87AF-500UG
                  $2,811.00
                    1 mg (Animal-Free) In Stock 200-87AF-1MG
                    $4,683.00
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                      Details

                      Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1α and the independently regulated IL-1β protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

                      Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

                      Instructions

                      Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

                      Technical Specifications

                      Alternate Names None
                      Accession Number P01582
                      Source Genetically modified E.coli
                      Predicted Molecular Mass Monomer, 18.1 kDa (157 aa)
                      AA Sequence MSAPYTYQSD LRYKLMKLVR QKFVMNDSLN QTIYQDVDKH YLSTTWLNDL QQEVKFDMYA YSSGGDDSKY PVTLKISDSQ LFVSAQGEDQ PVLLKELPET PKLITGSETD LIFFWKSINS KNYFTSAAYP ELFIATKEQS RVHLARGLPS MTDFQIS
                      Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
                      Product Reconstitution Sterile water at 0.1 mg/mL
                      Country of Origin USA

                       

                      Specification* Method of Determination Acceptance Criteria
                      Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
                      Endotoxin Kinetic LAL ≤ 0.1 EU/µg
                      Biological Activity (ED50) D10.G4.1 proliferation ≤ 0.01 ng/mL

                       

                      *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

                      IL-1alpha IL-1 alpha

                      Specifications

                      Storage
                      At or below -20°C
                      Shelf Life
                      12 months from date of receipt when stored at -20°C to-80°C as supplied.
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