Join Our Mailing List Today!

NOTICE: Online ordering will be disabled 1/27-2/3. Learn More.

Recombinant Mouse IL-17A

In stock
Catalog ID
200-59
Size Stock SKU Unit Price Qty
5 µg In Stock 200-59-5UG
$73.00
5 µg (Animal-Free) Inquire for Availability 200-59AF-5UG
$79.00
25 µg In Stock 200-59-25UG
$183.00
25 µg (Animal-Free) Inquire for Availability 200-59AF-25UG
$200.00
100 µg In Stock 200-59-100UG
$457.00
100 µg (Animal-Free) In Stock 200-59AF-100UG
$504.00
500 µg In Stock 200-59-500UG
$1,971.00
500 µg (Animal-Free) Inquire for Availability 200-59AF-500UG
$2,165.00
1 mg Inquire for Availability 200-59-1MG
$3,284.00
1 mg (Animal-Free) Inquire for Availability 200-59AF-1MG
$3,613.00
reset
Details

Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion.  In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites. Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names IL-17, CTLA-8
Accession Number Q62386
Source Genetically modified E.coli
Predicted Molecular Mass Dimer, 15.1/30.2 kDa (134/268 aa)
AA Sequence MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
Formulation Lyophilized from a 0.2 µm filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Product Reconstitution Sterile water at 0.1 mg/mL
Country of Origin USA

 

Specification* Method of Determination Acceptance Criteria
Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
Endotoxin Kinetic LAL ≤ 0.1 EUs/µg
Biological Activity (ED50) Production of IL-6 by mouse 3T3 cells ≤ 5 ng/mL

 

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage
At or below -20°C
Shelf Life
12 months from date of receipt when stored at -20°C to-80°C as supplied.
© 2024 FUJIFILM Irvine Scientific. All rights reserved.