Recombinant Human TPO (CHO)

In stock

Catalog ID

100-216

Size	Stock	SKU	Unit Price
5 µg	In Stock	100-216-5UG	$128.00
25 µg	In Stock	100-216-25UG	$457.00
100 µg	In Stock	100-216-100UG	$1,217.00
500 µg	In Stock	100-216-500UG	$5,171.00
1 mg	In Stock	100-216-1MG	$7,299.00

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Details

Thrombopoietin (TPO) is a growth factor that is produced by liver and kidney tissues. TPO binds the TPO receptor (CD110) to promote megakaryocyte maturation, differentiation, and the production of platelets. Human TPO (CHO) contains an C-terminal 6x-polyhistidine (6xHis) tag.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C, and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Megakaryocyte Colony Stimulating Factor, c-MPL ligand, MGDF
Accession Number	P40225
Source	Genetically modified CHO cells
Predicted Molecular Mass	Monomer, 36.3 kDa (338 aa)
AA Sequence	SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNELPNRTSG LLETNFTASA RTTGSGLLKW QQGFRAKIPG LLNQTSRSLD QIPGYLNRIH ELLNGTRGLF PGPSRRTLGA PDISSGTSDT GSLPPNLQPG YSPSPTHPPT GQYTLFPLPP TLPTPVVQLH PLLPDPSAPT PTPTSPLLNT SYTHSQNLSQ EGHHHHHH
Formulation	Lyophilized from a 0.2 µm filtered solution containing 5 mM sodium phosphate, 2 mM L-Arginine, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 90%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	MO7e cell proliferation	≤ 15 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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