Recombinant Human IL-1RA

In stock

Catalog ID

100-195

Size	Stock	SKU	Unit Price
20 µg	In Stock	100-195-20UG	$73.00
100 µg	In Stock	100-195-100UG	$183.00
250 µg	In Stock	100-195-250UG	$457.00
500 µg	Inquire for Availability	100-195-500UG	$790.00
1 mg	Inquire for Availability	100-195-1MG	$1,217.00
20 µg (Animal-Free)	In Stock	100-195AF-20UG	$79.00
100 µg (Animal-Free)	In Stock	100-195AF-100UG	$200.00
250 µg (Animal-Free)	Inquire for Availability	100-195AF-250UG	$499.00
500 µg (Animal-Free)	In Stock	100-195AF-500UG	$870.00
1 mg (Animal-Free)	In Stock	100-195AF-1MG	$1,338.00

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Details

Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	IL1RN, IL-1F3
Accession Number	P18510
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 17.3 kDa (153 aa)
AA Sequence	MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 1 EU/µg
Biological Activity (ED₅₀)	Inhibition of human IL-1 alpha induced proliferation of D10.G4.1 cells	≤ 50 ng/mL

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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