Recombinant Human IL-1β

In stock

Catalog ID

100-167

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-167-10UG	$190.00
100 µg	Inquire for Availability	100-167-100UG	$550.00
500 µg	In Stock	100-167-500UG	$2,732.00
1 mg	In Stock	100-167-1MG	$4,554.00
10 µg (Animal-Free)	In Stock	100-167AF-10UG	$208.00
100 µg (Animal-Free)	Inquire for Availability	100-167AF-100UG	$600.00
500 µg (Animal-Free)	Inquire for Availability	100-167AF-500UG	$3,005.00
1 mg (Animal-Free)	In Stock	100-167AF-1MG	$5,010.00

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Details

Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping pro-inflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	Catabolin, LAF, EP, LEM, MCF
Accession Number	P01584
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 17.5 kDa (154 aa)
AA Sequence	MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 1 EU/µg
Biological Activity (ED₅₀)	D10S cell proliferation	≤ 0.012 ng/mL; ≥ 8.3 x 10⁷ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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