Recombinant Human HB-EGF

In stock

Catalog ID

100-180

Size	Stock	SKU	Unit Price
10 µg	In Stock	100-180-10UG	$73.00
50 µg	In Stock	100-180-50UG	$183.00
100 µg	In Stock	100-180-100UG	$330.00
500 µg	In Stock	100-180-500UG	$839.00
1 mg	In Stock	100-180-1MG	$1,460.00
10 µg (Animal-Free)	In Stock	100-180AF-10UG	$79.00
50 µg (Animal-Free)	In Stock	100-180AF-50UG	$200.00
100 µg (Animal-Free)	In Stock	100-180AF-100UG	$359.00
500 µg (Animal-Free)	Inquire for Availability	100-180AF-500UG	$925.00
1 mg (Animal-Free)	In Stock	100-180AF-1MG	$1,607.00

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Details

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family and is expressed by monocytes and macrophages. HB-EGF is the predominant growth factor involved in epithelialization during wound healing. HB-EGF signals through the receptor tyrosine kinase ErbB2 to maintain adult heart homeostasis, and promotes cardiac valve development through binding in high affinity to the epidermal growth factor receptor (EGFR). HB-EGF binds the the ErbB4 receptor tyrosine kinase to mediate implantation of the human blastocyst. HB-EGF also functions as a potent mitogen for fibroblasts and smooth muscle cells.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	HBEGF, Diphtheria toxin receptor, DT-R
Accession Number	Q99075
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 9.9 kDa (87 aa)
AA Sequence	MDLQEADLDL LRVTLSSKPQ ALATPNKEEH GKRKKKGKGL GKKRDPCLRK YKDFCIHGEC KYVKELRAPS CICHPGYHGERCHGLSL
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	3T3 cell proliferation	≤ 1 ng/mL; ≥ 1.0 x 10⁶ units/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to-80°C as supplied.

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