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Recombinant Human FGF-21

In stock
Catalog ID
100-148
Size Stock SKU Unit Price Qty
5 µg Inquire for Availability 100-148-5UG
$73.00
    20 µg In Stock 100-148-20UG
    $183.00
      100 µg In Stock 100-148-100UG
      $457.00
        500 µg Inquire for Availability 100-148-500UG
        $1,971.00
          1 mg Inquire for Availability 100-148-1MG
          $3,284.00
            5 µg (Animal-Free) In Stock 100-148AF-5UG
            $79.00
              20 µg (Animal-Free) In Stock 100-148AF-20UG
              $200.00
                100 µg (Animal-Free) In Stock 100-148AF-100UG
                $504.00
                  500 µg (Animal-Free) Inquire for Availability 100-148AF-500UG
                  $2,165.00
                    1 mg (Animal-Free) Inquire for Availability 100-148AF-1MG
                    $3,613.00
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                      Details

                      Fibroblast growth factor 21 (FGF-21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF-21 is expressed in the liver, pancreas, heart, and adipose tissues. FGF-21 signaling is activated through the FGFR1c receptor and β-Klotho co-receptor. FGF-21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.

                      Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

                      Instructions

                      Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

                      Technical Specifications

                      Alternate Names FGFL
                      Accession Number Q9NSA1
                      Source Genetically modified E.coli
                      Predicted Molecular Mass Monomer, 19.5 kDa (182 aa)
                      AA Sequence MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELLLEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
                      Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, 100 mM sodium chloride, pH 7.5
                      Product Reconstitution Sterile water at 0.1 mg/mL
                      Country of Origin USA

                       

                      Specification* Method of Determination Acceptance Criteria
                      Purity Reducing and Non-Reducing SDS-PAGE ≥ 95%
                      Endotoxin Kinetic LAL ≤ 0.1 EU/µg
                      Biological Activity (ED50) NIH-3T3 proliferation with β-klotho and heparin ≤ 500 ng/mL; ≥ 2.0 x 103 unit/mg

                       

                      *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

                      Specifications

                      Storage
                      At or below -20°C
                      Shelf Life
                      12 months from date of receipt when stored at -20°C to -80°C as supplied.
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