Recombinant Human FGF-21

In stock

Catalog ID

100-148

Size	Stock	SKU	Unit Price
5 µg	Inquire for Availability	100-148-5UG	$76.00
20 µg	In Stock	100-148-20UG	$190.00
100 µg	In Stock	100-148-100UG	$475.00
500 µg	Inquire for Availability	100-148-500UG	$2,050.00
1 mg	Inquire for Availability	100-148-1MG	$3,415.00
5 µg (Animal-Free)	In Stock	100-148AF-5UG	$82.00
20 µg (Animal-Free)	In Stock	100-148AF-20UG	$208.00
100 µg (Animal-Free)	In Stock	100-148AF-100UG	$524.00
500 µg (Animal-Free)	Inquire for Availability	100-148AF-500UG	$2,252.00
1 mg (Animal-Free)	In Stock	100-148AF-1MG	$3,758.00

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Details

Fibroblast growth factor 21 (FGF-21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF-21 is expressed in the liver, pancreas, heart, and adipose tissues. FGF-21 signaling is activated through the FGFR1c receptor and β-Klotho co-receptor. FGF-21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.

Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

Instructions

Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

Technical Specifications

Alternate Names	FGFL
Accession Number	Q9NSA1
Source	Genetically modified E.coli
Predicted Molecular Mass	Monomer, 19.5 kDa (182 aa)
AA Sequence	MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELLLEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Formulation	Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, 100 mM sodium chloride, pH 7.5
Product Reconstitution	Sterile water at 0.1 mg/mL
Country of Origin	USA

Specification*	Method of Determination	Acceptance Criteria
Purity	Reducing and Non-Reducing SDS-PAGE	≥ 95%
Endotoxin	Kinetic LAL	≤ 0.1 EU/µg
Biological Activity (ED₅₀)	NIH-3T3 proliferation with β-klotho and heparin	≤ 500 ng/mL; ≥ 2.0 x 10³ unit/mg

*Lot-specific values for the above specifications are supplied with each product on its corresponding COA. The values provided here are minimum expected values to pass internal requirements.

Specifications

Storage

At or below -20°C

Shelf Life

12 months from date of receipt when stored at -20°C to -80°C as supplied.

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