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Recombinant Human Amphiregulin

In stock
Catalog ID
100-206
Size Stock SKU Unit Price Qty
10 µg Inquire for Availability 100-206-10UG
$73.00
    50 µg Inquire for Availability 100-206-50UG
    $183.00
      100 µg Inquire for Availability 100-206-100UG
      $341.00
        500 µg Inquire for Availability 100-206-500UG
        $913.00
          1 mg In Stock 100-206-1MG
          $1,702.00
            10 µg (Animal-Free) Inquire for Availability 100-206AF-10UG
            $79.00
              50 µg (Animal-Free) Inquire for Availability 100-206AF-50UG
              $200.00
                100 µg (Animal-Free) Inquire for Availability 100-206AF-100UG
                $378.00
                  500 µg (Animal-Free) Inquire for Availability 100-206AF-500UG
                  $1,004.00
                    1 mg (Animal-Free) Inquire for Availability 100-206AF-1MG
                    $1,874.00
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                      Details

                      Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.  AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR).  AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis. In a cancer context, AR protects against human adenocarcinoma apoptosis, promotes tumor cell growth, and functions as an oncogenic factor in the Hippo pathway. AR levels are increased in the brain following stress events, such as inflammation, ischemia, and hypoxia.

                      Product images on the website are not representative of actual product, including, but not limited to differences in cap color, tube type, or label format.

                      Instructions

                      Centrifuge vial before opening.  Suspend the product by gently pipetting the above recommended solution down the sides of the vial.  DO NOT VORTEX.  Allow several minutes for complete reconstitution.  For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

                      Technical Specifications

                      Alternate Names AR, AREG, Colorectum cell-derived growth factor, CRDGF
                      Accession Number P15514
                      Source Genetically modified E.coli
                      Predicted Molecular Mass Monomer, 10.1 kDa (87 aa)
                      AA Sequence SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMK
                      Formulation Lyophilized from a 0.2 µm filtered solution containing 10 mM sodium phosphate, pH 7.5
                      Product Reconstitution Sterile water at 0.1 mg/mL
                      Country of Origin USA

                       

                      Specification* Method of Determination Acceptance Criteria
                      Purity Reducing and Non-Reducing SDS PAGE ≥ 95%
                      Endotoxin Kinetic LAL ≤ 0.1 EU/µg
                      Biological Activity (ED50) 3T3 Cell Proliferation ≤ 20 ng/mL

                       

                      *Lot-specific values for the above specifications are supplied with each product on its corresponding COA.  The values provided here are minimum expected values to pass internal requirements.

                      Specifications

                      Storage
                      At or below -20°C
                      Shelf Life
                      12 months from date of receipt when stored at -20°C to -80°C as supplied.
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