Recombinant Human TNF-alpha ACF

In stock
Catalog ID
95117
Size Stock SKU Unit Price Qty
10 µg Inquire for Availability 95117-10µg
$99.00
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Details

Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic inflammatory cytokine produced predominantly by inflammatory monocytes and macrophages, but other cell types, including neutrophils, endothelial cells, lymphocytes, and activated tissue cells, can also be a source during overwhelming inflammatory responses. TNF-alpha has both beneficial and destructive properties for the central nervous system and affects lipid metabolism, coagulation, and endothelial function. The increasing release of TNF-alpha may contribute to the odds of ischemic stroke in patients. TNF-alpha is a primary mediator of numerous immunologic functions, which include stimulating phagocytosis in macrophages, chemoattraction of neutrophils, increased insulin resistance, and inducing fever. As a central player in the cytokine network, TNF-alpha has been implicated in a variety of disease states, including cachexia, septic shock, acute respiratory distress syndrome, and a number of necrotic, proliferative and autoimmune diseases. TNF-alpha activates signals through two receptors, TNFR1, which is expressed on most cell types, and TNFR2, which is expressed mainly on immune cells . TNF-alpha exists in both secreted and membrane bound forms, both bioactive (1-5). Recombinant Human TNF-alpha is a non-glycosylated protein, containing 158 amino acids, with a molecular weight of 17.5 kDa.

  • Accession Number: P01375
  • Synonyms: TNFSF2, Cachectin, DIF, Necrosin, Cytotoxin, Cachexin, TNF, TNF-α
  • Purity: ≥96% purity. Determined by reducing and non-reducing SDS-PAGE analysis.
  • Bioactivity: ED50 is determined by the cytolysis of mouse L929 cells in the presence of Actinomycin D. The ED50 is typically less than 0.8ng/mL.
  • Animal component-free and carrier-free
  • Custom packaging available

For research or further manufacturing use only.

Also available in other sizes.

Specifications

Storage
This product is shipped with dry ice. Upon receipt, store the medium at or below -10°C in a manual defrost freezer.
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