IL-4 is a pleiotropic cytokine produced mainly by a subpopulation of activated T cells called T helper 2 (Th2). It is also produced by T helper 1 (Th1) cells and mast cells. Biological activities of IL-4 are mediated by specific receptors expressed in a variety of cell types (helper T cells, endothelial cells, mast cells and macrophages). IL-4 has a wide range of effects on both hematopoietic cells and non-hematopoietic cells, such as smooth muscle and epithelial cells. Human IL-4 share 50% sequence homology with murine IL-4, but its activities are species-specific; human IL-4 shows no activity on murine cells. Recombinant Human IL-4 is a non-glycosylated protein, containing 130 amino acids with a molecular weight of 15 kDa.
Accession Number: P05112
Synonyms: B cell Stimulating Factor, BSF-1, BCDF, BCGF
Purity: ≥ 95% purity. Determined by HPLC, reducing and non-reducing SDS-PAGE, and UV spectroscopy
Bioactivity: ED50 typically less than 0.5 ng/mL. ED50 determined by dose-dependent proliferation of human TF1 cells.
Animal component-free and carrier-free
Custom packaging available
For research or further manufacturing use only.
Also available in other sizes.
This product is shipped with dry ice. Upon receipt, store the medium at or below -10°C in a manual defrost freezer.