Recombinant Human IL-2 ACF

In stock
Catalog ID
95118
Size Stock SKU Unit Price Qty
10 µg In Stock 95118-10µg
$99.00
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Details

IL-2 is a T cell stimulatory cytokine best known for inducing activated T cell proliferation in vitro. IL-2 also stimulates proliferation and differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 is critical for the development, survival, and function of CD4+CD25+ regulatory T cells, which promotes T cell tolerance by suppressing T cell responses to self-antigens in vivo, thus inhibiting immune responses and preventing autoimmune diseases. IL-2 plays an essential role in sensitizing T cells to activation-induced cell death, a process mediated primarily by Fas and TNF signals to limit the magnitude of T cell expansion through programmed death of activated T cells. IL-2 binds to and signals through membrane receptor IL-2R, which is expressed almost exclusively by activated T-cells. IL-2R is a trimeric receptor complex consisting of three distinct subunits designated as IL-2Rα (CD25), IL-2Rβ (CD122), and common γ-chain (γc, CD132). IL-2Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex, including IL-2Rβ and γc subunits. IL-2Rβ is also used by IL-15. The common γc is used by other cytokines, including IL-4, IL-7, IL-9, IL-15, and IL-21. Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (2-5). Recombinant Human IL-2 ACF has a serine substitute for cysteine at position 126. Recombinant Human IL-2 ACF is a non-glycosylated protein, containing 134 amino acids, with a molecular weight of 15.5 kDa.

  • Accession Number: P60568
  • Synonyms: T cell growth factor, TCGF, Aldesleukin
  • Purity: ≥90% determined by reducing and non-reducing SDS-PAGE analysis
  • Bioactivity:  The ED50 is typically less than 1 ng/mL. ED50 is determined by the dose-dependent proliferation of CD3+ T cells.
  • Animal component-free and carrier-free
  • Custom packaging available

For research or further manufacturing use only.

Also available in other sizes.

Specifications

Storage
This product is shipped with dry ice. Upon receipt, store the medium at or below -10°C in a manual defrost freezer.
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