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Offering the ability to scale-up to various automated bioreactors with increased speed for T cell culture, PRIME-XV T Cell CDM is fully optimized for immune therapy and research. Chemically defined and animal component-free, it delivers consistent growth while maintaining T cell functionality and potency in scalable therapy or research.

Size Stock SKU Unit Price Qty
1 L In Stock 91154-1L

PRIME-XV T Cell CDM is the first commercially available chemically defined, animal component-free medium for the expansion and cultivation of human T cells. The performance and functionality of PRIME-XV T Cell CDM continues to set the standard as the application process becomes more dynamic and closed.

Provides optimal performance:

  • Supports vigorous T cell growth in static and dynamic automation systems while maintaining functionality
  • Provides lot-to-lot consistency for reliable formulation composition
  • Removes the effects of undefined components to minimize unwarranted T cell phenotypes
  • Supports polarization to targeted T cell types such as Th1 and T regulatory cells to further possible therapy applications

Manufactured to facilitate transfer from research to clinic:

  • Chemically defined, animal component-free formula minimizes risks from adventitious agents
  • Manufactured in compliance with cGMP regulations
  • Traceability documentation provided including Certificates of Analysis, Certificates of Origin, and a Drug Master File (DMF) filed with the US FDA
  • Extensive QC testing including functionality, sterility, and endotoxin
  • Mycoplasma USP <63> testing is standard on all lots
  • Custom formulation, sizes and packaging available for all commercially available automation systems

PRIME-XV T Cell CDM supports viable T cell expansion across different culture vessels

Figure 1: (A) Fold expansion of CD3+ cells in PRIME-XV T Cell CDM is robust across the three documented culture systems, performing as well as or better than FBS-supplemented RPMI and commercially available XSF media. (B) Viability is maintained at or above 85% by the end of the culture period in all three cell culture systems. Though significant inter-donor variability is observed, these data are representative of three donors, analyzed on day 14 (plates, flasks and G-Rex) or day 9 (Quantum bioreactors).

Publication, presentation, and protocol available for download

  • Protocols support G-Rex and Quantum
  • Protocols for plates and flasks can be provided upon request


This product is shipped at 2-8°C with cold packs. Upon receipt, store immediately at 2-8°C and protect from light.
Shelf Life
Handle using aseptic techniques to avoid contamination. Unopened liquid medium is stable for 24 months from date of manufacture, as indicated on the label.
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