An efficient bioprocessing workflow is critical for the timely production of biologics and therapies. Visit Booth #521 at Biotech Week Boston to learn how FUJIFILM Irvine Scientific can partner with you to provide the expertise, responsiveness, and flexibility to speed therapies to market.

Main Track Presentations

Title: Improved Cell Productivities for Fed-batch and Perfusion Processes with BalanCD CHO Media Platform
Presenter: Luis G. Rodriguez, PhD, R&D Manager, Bioproduction
Date: Tuesday, September 19, 2023
Time: 10:10 AM EST

Efficient production of monoclonal antibodies (mAbs) in CHO cells requires optimized cell culture solutions upstream. Whether it is fed-batch or perfusion processes for the commercial manufacture of biomolecule therapeutics, identifying an appropriate medium for your cell culture process is key for successful scale-up and manufacture.

Introducing chemically defined (CD) media that deliver increased cell productivities in perfusion and fed-batch modes for bioprocessing applications: BalanCD CHO Perfusion and BalanCD CHO DG44 from FUJIFILM Irvine Scientific. Designed to support high cell density and high steady-state cultures for improved cell-specific productivities, these high-performing media provide cost-effective solutions for mAb production.

Learn How to:

• Optimize CHO fed-batch and perfusion cultures for high cell density with CD media
• Maximize cell growth, titer, and cell-specific productivity for fed-batch and perfusion processes
• Achieve cost-effective production of biotherapeutics
• Improve perfusion productivities at higher steady-states by optimizing perfusion culture parameters in a push-to-low strategy

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Title: Delivering Improved Bioprocessing Workflows with Manufacturing Science and Technology (MSAT): A Case Study for Cell Culture Solutions
Presenter: Ishmael Ordonez, PhD, R&D Manager, Process Development – MSAT Services
Date: Thursday, September 21, 2023
Time: 10:00 AM EST

The key challenges in cell culture media preparation typically include hydration, solubility, and precipitation, all of which may ultimately affect media consistency and performance. To meet the evolving demands of bioprocessing and biologics manufacture, Manufacturing Science and Technology (MSAT) services can help simplify process workflows, increase process efficiencies, and overcome technical challenges.

FUJIFILM Irvine Scientific is dedicated to creating value through innovation and fostering collaboration with customers. Through the MSAT and Media Development and Optimization (MDO) services, we help our customers achieve their goals towards the development of life-saving therapeutics. In this presentation, we provide an overview of MSAT services and present a case study of how MSAT was utilized to address a copper precipitation issue in cell culture.

Learning Objectives:

• Discover MSAT approaches for improving upstream bioprocessing workflows
• Identify risks and bottlenecks in media preparation and manufacturing
• Explore ways to improve the reliability and productivity of media
• Addressing media precipitation in bags: a case study on copper precipitation

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Featured Posters

• Development of a Chemically Defined Growth Medium Specifically Designed for CHO DG44 Cells
• Predicting the Performance of Perfusion Media in a Continuous Bioreactor from Small-Scale Perfusion Mimics
• Chemically Defined BalanCD HEK293 Viral Feed Boosts Viral Vector Production
• Developing User-Friendly Cell Culture Media
• Adaptation of Adherent HEK293T Cells to Suspension Cell Culture in Chemically Defined Culture Medium

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