PDGF-BB belongs to the family of disulfide-linked homodimeric and heterodimeric growth factors. PDGF is expressed in different cell types and stored in platelet granules released upon platelet activation. PDGF isoforms are potent mitogens for connective tissue cells and can induce chemotactic responses in fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. PDGF also appears to play an important role in neuron survival and regeneration. Recombinant Human PDGF-BB is a non-glycosylated, disulfide linked homodimer, containing two 109 amino acid chains, with a total molecular weight of 24.3 kDa.
Accession Number: P01127
Synonyms: GDGF, ODGF
Purity: ≥ 95% purity. Determined by HPLC, reducing and non-reducing SDS-PAGE, and UV spectroscopy
Bioactivity: ED50 typically less than 15 ng/mL. ED50 determined by dose-dependent proliferation of human 3T3 cells.