Insulin-like growth factor 1 (IGF-1) is produced primarily by the liver as an endocrine hormone and in target tissues in a paracrine/autocrine fashion. IGF-1 activates the IGF-1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth and growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung cells. IGF-1 is a potent activator of the AKT signaling pathway, which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. The IGF-1 gene is located on chromosome 12. Mature human IGF-1 is 100% homologous with bovine and porcine proteins. Recombinant Human IGF-1 ACF is a non-glycosylated protein, containing 70 amino acids, with a molecular weight of 7.7 kDa (2-4).
- Accession Number: P05019
- Synonyms: Somatomedin C, mechano growth factor, IGF-1A
- Purity: ≥96% determined by reducing and non-reducing SDS-PAGE analysis
- Bioactivity: The ED50 is typically less than 5 ng/mL. ED50 is determined by the dose-dependent proliferation of FDC-P1 cells.
- Animal component-free and carrier-free
- Custom packaging available
For research or further manufacturing use only.
Also available in other sizes.