Optimize, Automate, and Scale Closed-System MSC Expansion

January 10, 2025

As MSCs become more popular in regenerative medicines and cell therapies, the ability to automate the manufacturing of MSC-based therapies efficiently is paramount to bring them to market. Automation helps achieve target quantities and quality at an economical production cost. Unlike immunotherapy, regenerative medicine applications using MSCs require basal media and a full complement of supplement growth factors.

Closed-System Ready

Introducing PRIME-XV MSC XSFM Dual Component Kit with or without Phenol Red. Comprised of xeno-free PRIME-XV MSC XSFM basal medium and supplement, this dual bag kit is intended for functionally closed hollow-fiber platforms like Quantum Flex, and offers an optimized solution for MSC expansion. It is the only closed-system solution that includes both elements for a streamlined manufacturing process with Quantum Flex or other hollow-fiber bioreactors. The system further reduces variability by supporting high expansion rates and viability in a closed environment, providing consistent results while enabling scalability and automation.

The PRIME-XV MSC XSFM Dual Component Kit is specifically designed to take advantage of the large-scale approach typical to hollow-fiber bioreactors, utilizing a bag-to-bioreactor construction that makes set up and scale-up simpler, faster, and more reliable. Some other advantages include:

• Seamless scale-up with less optimization needed from research to manufacturing
• Greater control with lower risks from adventitious agents and manual handling due to the sterile, automated closed system
• Reduced freezer storage space and thaw time

Same Trusted Formula

The original PRIME-XV MSC XSFM is an established product of the FUJIFILM Irvine Scientific portfolio. It is formulated to support optimal and reliable expansion of human MSCs while retaining morphology, marker expression, immunosuppressive function, and differentiation potential over multiple passages.

Manufactured under GMP guidelines, the xeno-free, serum-free formulation minimizes risk of adventitious agents and delivers lot-to-lot consistency. It is available with or without phenol red and yields up to 200 x 10⁶ cells in seven days of expansion with more than 90% viability. The addition of the PRIME-XV MSC XSFM Dual Component Kit gives manufacturers access to one of our most trusted formulations in a new format. Ensuring that no matter what therapy development process they choose, we have the solution.

Complete Workflow Solutions for Cell Therapy

By providing innovative, first-to-market products and workflow solutions, we holistically accelerate user efforts with complete media solutions for basic, translational, and clinical research, as well as commercial applications. We have cultivated deep industry insights and cell culture media expertise—positioning us as the partner of choice to support your cell and gene therapy media needs.

Ready to optimize your MSC expansion workflow? Contact one of our experts to discover how we can help you.

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