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Research Scientist

Research & Development | Warminster, PA

Job Description:

We are hiring a Research Scientist. The Research Scientist will be responsible for conducting research and development leading to the development of new products and process optimization of the selected existing product to increase the yield in manufacturing. The Research Scientist will also conduct protein purification at manufacturing scale under the direction of a supervisor.

Responsibilities:

  • Lead and drive protein purification process development activities (existing product and new product), with a focus on optimizing yield, purity, and scalability
  • Design and implement robust purification strategies utilizing a range of chromatographic techniques
  • Apply in-depth knowledge of downstream processing to ensure seamless transition from lab-scale to production-scale operations
  • Supervise and conduct experimental work related to new product development
  • Oversee and mentor Associate scientists, providing guidance on experimental design, data analysis, and troubleshooting
  • Perform protein manufacturing following the purification batch record
  • Draft SOPs, batch record templates and associated documentation
  • Conduct thorough protein characterization and analysis, assist in trouble shooting equipment and experimental problem
  • Collaborate closely with cross-functional teams, including quality control and quality assurance to meet project milestones and goals
  • Contribute to development of long-range plans for R&D
  • Learn, maintain and advance expertise in areas relevant to company’s products and strategic goals
  • Present data to the department and project teams

Required Skills/Education:

  • Bachelors in a Biological/Chemical Science plus 6+ years, Masters with 4+ years, or PhD with 1+ years in a Biological/Chemical Science, plus relevant work experience with proteins
  • Relevant work experience with proteins and purification techniques are required
  • Expertise in protein purification techniques, including chromatography (e.g., affinity, ion-exchange, size exclusion), Depth-filtration, TFF and protein analysis methods required
  • Experience in purification of proteins from inclusion bodies including optimization of protein renaturation/refolding
  • Broad experience with recombinant protein construct design
  • Broad experience with analytical protein characterization methods, including HPLC, SDS-PAGE, IEF, Nano UV-Vis, Western-blot, MS/MS and TOF mass spec, SEC-MALS
  • Experience with experimental design including DoE methods
  • Experience in protein purification scale-up preferred
  • Preferable expertise on protein formulation development, design buffer formulations to enhance protein solubility, stability, and shelf-life, develop lyophilization protocol with cryoprotectants and lyoprotectants
  • Ability to speak, read and write English proficiently
  • Good oral and written communication skills

Benefits:

  • Medical, Dental, Vision
  • Life Insurance
  • 401k
  • Paid Time Off

 

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If you require reasonable accommodation in completing this application, interviewing, completing any pre-employment testing, or otherwise participating in the employee selection process, please direct your inquiries to our HR Department (fisihr@fujifilm.com).

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