Recombinant Human FLT-3 Ligand ACF

Catalog ID: 95120

95120 - Recombinant Human FLT-3 Ligand ACF
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Recombinant Human FLT-3 Ligand ACF
95120 - 10 µg Login above or Register for pricing

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FLT-3 Ligand is a member of the “potentiating” group of hematopoietic growth factors that stimulate the proliferation of hematopoietic cells. Other members of this family include stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). FLT-3 Ligand has minimal proliferative activity on its own, but can synergize with a wide range of other colony stimulating factors and interleukins to stimulate proliferation. FLT-3 Ligand binds to, and transmits signals through, the receptor tyrosine kinase known as FMS-like tyrosine kinase-3 (FLT-3). FLT-3 Ligand exerts a marked stimulatory action on primitive hematopoietic progenitor cells and a unique expanding effect on putative stem cells. The distal proliferative/differentiative action of FLT-3 Ligand is largely restricted to granulomonocytic progenitors and monocytic precursors. FLT-3 Ligand does not affect the growth of erythroid committed progenitors. Expression of the FLT-3 receptor is essentially restricted to early hematopoietic progenitor cells in a quiescent status and progenitors undergoing granulomonocytic differentiation, suggesting differential expression of the FLT-3 receptor underlies the selective stimulatory effect of FLT-3 Ligand. FLT-3 Ligand also plays an important role in lymphopoiesis. FLT-3 Ligand promotes long-term expansion and differentiation of human pro-B cells in the presence of IL-7 or in combination of IL-7 and IL-3. At least two cytokines have been identified to block FLT-3 Ligand-induced or potentiated hematopoietic activitys: TNF-alpha and TGF-beta (2-4). Human FLT-3 Ligand can stimulate the proliferation of cells expressing murine FLT-3 receptors. Recombinant Human FLT-3 Ligand ACF is a non-glycosylated protein containing 155 amino acids, with a molecular weight of 17.6 kDa.

  • Accession Number: P49771
     
  • Synonyms: FLT3L, Fms-related tyrosine kinase 3 ligand
     
  • Purity: ≥ 98% determined by HPLC, reducing and non-reducing SDS-PAGE, UV spectroscopy at 280 nm.
     
  • Bioactivity: The ED50 is typically less than 5 ng/mL. ED50 is determined by dose-dependent proliferation of OCI-AML5 cells.
     
  • Animal component-free and carrier-free
     
  • Custom packaging available

For research or further manufacturing use only.

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Storage

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