Recombinant Human EGF ACF

Epidermal growth factor (EGF) is a protein that plays an important role in the regulation of various cell processes, including cell proliferation, migration, survival, and differentiation. EGF is a member of the EGF family that binds to the EGFR family of receptors (also known as ErbB receptors). The ErbB receptors consist of four transmembrane receptors belonging to the receptor tyrosine kinase (RTK) superfamily and includes EGFR (ErbB1/HER-1), ErbB2 (neu/HER-2), ErbB3 (HER-3), and ErbB4 (HER-4). Functional selectivity of EGF family members is due to distinctions in the conformation of the liganded receptor and subsequent differences in the sites of receptor tyrosine phosphorylation and receptor coupling to signaling effectors. Recombinant Human EGF ACF is a single, non-glycosylated protein containing 53 amino acids, with a molecular weight of 6.2 kDa (1-3).

• Accession Number: P01133
   
• Synonyms: Urogastrone, URG
   
• Purity: ≥95% determined by HPLC, reducing and non-reducing SDS-PAGE analysis, UV spectroscopy at 280nm.
   
• Bioactivity: The ED₅₀ is typically less than 15 pg/mL. ED₅₀ is determined by dose-dependent proliferation of BALB/c 3T3 cells.
   
• Animal component-free and carrier-free
   
• Custom packaging available

For research or further manufacturing use only.

Also available in other sizes.