Serum-free and chemically-defined media offer customers better lot-to-lot consistency because they contain fewer undefined components, such as serum. Chemically-defined media contains components that are all known.
Chinese Hamster Ovary (CHO) cells are used in the study of genetics, nutrition, and gene expression, and are the most commonly used mammalian host for commercial production of recombinant protein therapeutics.
Serum-free and chemically-defined media are lower in protein content than media supplemented with serum, which can simplify the purification process and increase the yield of the end product. These products are free of animal-derived components, and only contain known chemical components.
Serum-free media is supplemented with hydrolysates to improve growth and production.
Hybridoma cells are a hybrid of a lymphocyte (usually a B-Cell) and a myeloma cancer cell. These cells are useful since they can produce monoclonal antibodies as opposed to polyclonal antibodies.