Solutions for Cell Freezing and Hypothermic Preservation

Irvine Scientific’s biopreservation products are formulated as chemically-defined, protein-free solutions that are manufactured under GMP. PRIME-XV® FreezIS and PRIME-XV Hypothermic Preservation Solution require no additional components and are available in custom packaging sizes.

About Cell Preservation

The ability to preserve primary and stem cells via cell freezing and hypothermic preservation has provided tremendous potential for allogeneic and autologous transplants for clinical therapeutic applications. Once a cell line is established for study or treatment, it is important to store it for future use. Cell freezing offers a method to preserve cells for a prolonged period of time by storing it at temperatures ranging for -80°C to -196°C. For shorter terms, hypothermic preservation at 2°C to 8°C is another alternative. An effective cell freezing or preservation solution will additionally ensure that these cells will thaw out with minimal loss in integrity and activity.

PRIME-XV® FreezIS enables cell freezing of a variety of cell types, ranging from human mesenchymal stem cells and induced pluripotent stem cells to rat neural progenitor cells. After cryogenic preservation, cells were validated for cell markers, viability, and fold expansion over multiple passages. PRIME-XV FreezIS follows a slow freezing process to reduce damage from cold shock.


PRIME-XV® Hypothermic Preservation Solution provides a novel method of storing and shipping biologics at 2°C to 8°C, and reduces the cellular stress response from the chilling and re-warming of cells and tissues. PRIME-XV Hypothermic Preservation Solution is a safer and easier method of biopreservation that is ideal for short term storage or cells that are sensitive to freezing temperatures.


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